Hypertonic Saline in Bronchiolitis and Type I Error: A Trial Sequential Analysis

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چکیده

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Normal Saline vs. Hypertonic Saline Nebulization for Acute Bronchiolitis: A Randomized Clinical Trial

BackgroundWe aimed to compare the efficacy of nebulized hypertonic (3%, 5% and 7%) saline with normal saline in hospitalized infants with acute bronchiolitis.Materials and MethodsIn this triple-blinded randomized clinical trial, 120 children with moderate to severe bronchiolitis randomly assigned into four groups to receive nebulized normal saline (group A),  saline 3% (group B), saline 5% (gro...

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7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial

This randomized controlled trial compared 7% hypertonic saline versus 0.9% (normal) saline, in addition to racemic epinephrine (in both groups), among infants with mild to moderate severity bronchiolitis. The authors used a modification of the oft-applied bronchiolitis severity score (BSS) by Wang, et al. [1] to evaluate the efficacy of treatment at multiple time points until discharge/ disposi...

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7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial

BACKGROUND: Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared with 0.9% saline mixed with epinephrine. To our knowledge, 7% HS has not been previously investigated....

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7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial

BACKGROUND: Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared with 0.9% saline mixed with epinephrine. To our knowledge, 7% HS has not been previously investigated....

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7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial.

BACKGROUND Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared with 0.9% saline mixed with epinephrine. To our knowledge, 7% HS has not been previously investigated. ...

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2018

ISSN: 0031-4005,1098-4275

DOI: 10.1542/peds.2018-1144